Environmental Health and Safety (EHS)

Chemical Safety Division - Chemical Safety Committee

Meeting Dates | Guidelines | Classes of Chemicals
Submission/Review Process | Animal Studies | Resources | Contacts


The Chemical Safety Committee serves in an advisory and consultative capacity to the President and the Vice President for Research, and to work with the Environmental Health and Safety Office in matters pertaining to the safe receipt, use, storage, and disposal of hazardous chemicals, review safety standards involving chemicals prior to promulgation and execution, review plans for chemical safety programs (those required and/or those not required by law or by granting/contracting agency) in order to determine their applicability to the research/training function of the Health Science Center; in matters pertaining to the safe receipt, use, storage, and disposal of hazardous chemicals; and to serve as an avenue of appeal in cases of dispute and exception.


Meeting Dates – for FY 2016-2017 are as follows:

Thursday, November 3, 2016 (12:00 pm – 1:00 pm)
Thursday, February 2, 2017 (12:00 pm – 1:00 pm)
Thursday, May 4, 2017 (12:00 pm – 1:00 pm)
Thursday, August 3, 2017 (12:00 pm – 1:00 pm)


Location: 4.074 Library (Long Campus)



Guidelines for Submitting CSC Protocols

Scope: The Chemical Safety Committee has established requirements for Principal Investigators whose research protocols involve the use of certain hazardous chemicals that pose a significant health risk to employees.   These protocols are reviewed by the Committee to ensure safe and proper measures are practiced regarding use, containment, storage and disposal, in an effort to reduce or eliminate occupational exposures.  Approval is required prior to using certain chemicals in the lab.





Classes of Chemicals Requiring CSC Approval

  1. Carcinogens – any chemical which meets one of the following criteria:
    1. Listed under Group 1 (carcinogenic to humans) or Group 2A (probably carcinogenic to humans) by the International Agency for Research on Cancer Monographs (IARC).
    2. Listed as “Known to be Human Carcinogens” in the Annual Report on Carcinogens published by the National Toxicology Program (NTP).
    3. Listed under the Occupational Safety & Health Administration (OSHA), 29 CFR 1910.1003. 

Examples include, but not limited to Streptozotocin, DMBA, 12-0-Tetradecanoyl-phorbol-13-acetate (TPA), and 3-methylcholanthracene.  For the complete lists from IARC, NTP and OSHA, please refer to the Chemical Safety Handbook, Appendix C, C-1, and C-2.  

  1. Antineoplastic Agents – chemotherapy and cytotoxic drugs used in cancer therapy.  Examples include Cyclophosphamide, Tamoxifen, Cisplatin, Daunorubicin, and Doxorubicin Hydrochloride.
  2. Mutagens – chemical agents that alter DNA.  Mutagens are also typically carcinogens.  Examples include Urethane, Ethyl methanesulfonate, and Bromodeoxyuridine (BRDU).
  3. Select Agent Toxins and other Toxins – Select Agent Toxins have the potential to pose a severe threat to animal health and safety, plant health and safety.  Examples include tetrodotoxin and botulinum neurotoxin.  Other toxins that would require CSC approval include cholera toxin (subunit A) and pertussis toxin.
  4. Highly Toxic Chemicals – chemicals that have a high degree of acute toxicity.  These agents meet the following criteria:
    1. Median lethal dose (LD50) of 50 mg or less when administered orally to rats [LD50 < 50 mg/kg].
    2. Median lethal dose (LD50) of 200 mg or less when administered by continuous dermal contact for 24 hours (or less if death occurs within 24 hours) to the skin of rabbits [LD50 < 200 mg/kg].
    3. Median lethal concentration (LC50) in air of 200 parts per million by volume when administered by continuous inhalation for one hour (or less if death occurs within one hour) to rats [LC50 < 200 ppm].

Examples include sodium arsenite, mercury, cadmium, and osmium tetroxide.

  1. Pesticides, Insecticides, Herbicides – defined as “any substance or mixture of substances intended for preventing, destroying, repelling, or mitigating any pest” by the Federal Insecticide, Fungicide, and Rodenticide Act.  Examples include Paraquat, Diquat, and Chlorpyrifos. 
  2. Pyrophoric Chemicals – substances that will ignite spontaneously upon contact with air.  Examples include tertiary-butyl lithium, iron sulfide, and many reactive metals.
  3. Nanoparticles – is defines as a small particles (1 - 100 nanometers) that behave as a whole unit in terms of its transport and properties.  Some nanoparticles, such as Zinc Oxide, are thought to have cytotoxic properties. 
  4. Neurotoxins – chemical agents that can affect the transmission of signal between neurons.  Examples include MPTP and snake venom.

For other highly hazardous chemicals that do not fall under these categories, please contact Chemical Safety Manager, Rebecca Bloodworth (Bloodworth@uthscsa.edu) at 567-2963 for assistance or to verify if a specific chemical requires CSC approval.





Protocol Submission and Review Process

Chemical Protocols are reviewed on a continuous basis by the Committee.  Chemical Protocols are usually approved within 30 calendar days of assignment to the Reviewers.   It is highly recommended that protocols are submitted well in advance of any funding or other agency deadlines.  Principal Investigators must submit chemical protocols through the EH&S system EH&S Assistant.  Appointment may be made with Rebecca Bloodworth, Chemical Safety Manager, for assistance in creating and submitting chemical protocols.  Below is a step by step description of the submission and review process:

  1. All submitted protocols are reviewed by the Manager.  Incomplete protocols, or questions requiring attention from the PI, will be returned to the PI for clarification.
  2. Once the PI has adequately addressed the Manager’s concerns, the protocol will be assigned to Committee Reviewers.  Reviewers have the option to either recommend the protocol for approval, or submit comments to the PI.
  3. Reviewer comments may be submitted to the PI, if marked as “Necessary for Approval”.  The Manager will return the protocol to the PI, who is then asked to respond.
  4. After the PI has addressed all Reviewer comments, the protocol is re-submitted, and a second review cycle begins.
  5. After all Reviewer questions have been addressed, and a majority of the Assigned Reviewers approves the protocol, the Manager will finalize approval.  An approval letter will be published for the PI to view. 




Animal Studies Involving Hazardous Chemicals

Principal Investigators with animal protocols involving in vivo exposure to any of the categories of chemicals listed above must have CSC approval to use these agents in live animals.  Please bear in mind that IACP requires Safety approval for any of the chemical categories listed above.  It is imperative that CSC protocols are submitted early so as not to delay IACUC approval.

  • If prior CSC approval has been granted for general laboratory use, the PI will only have to submit an amendment through E-Protocol.   
    • Appendix A of the chemical application must be completed and submitted with your amendment.
    • Attach a copy of your IACUC protocol with your amendment.


  • If CSC approval is not on file, the PI must submit (concurrently with IACUC submission) a new CSC protocol through E-Protocol. 


For assistance with submitting chemical safety protocols, please contact Rebecca Bloodworth, Bloodworth@uthscsa.edu, at (210) 567-2963. 










Rebecca Bloodworth, CHMM

Chemical Safety Manager


Phone: (210) 567-2963


Michael Charlton, PhD

Assistant VP for Risk Management & Safety


(210) 567-2955


Michael Huber, D.D.S.

Committee Chair


(210) 567-3360