DLAR - Medical Care - UTHSCSA Laboratory Animal Programs

Rat Anesthesia
Anesthesia	Concentration	Dose and Route	Onset	Duration of Surgical Anesthesia
Rat Cocktail (Ketamine, Xylazine)	Ketamine 60mg and Xylazine 8mg per ml of cocktail	0.1-0.2ml/250g IM, IP	3-5 minutes	30-40 minutes
Isoflurane (need precision vaporizer to deliver the agent)	induction 4-5% maintenance 1-2%	Inhalation	2-3 minutes	until disconnected
Halothane (need precision vaporizer to deliver the agent)	induction 4-5% maintenance 1-2%	Inhalation	2-3 minutes	until disconnected
Medetomidine* + Fentanyl (combination)	M = 1mg/ml F = 50µ gm/ml	300mg/kg IP 300µ gm/kg IP	2 minutes	30 minutes
Medetomidine* + Ketamine	M = 1mg/ml K = 100mg/ml	0.5 mg/kg IM, SC 75mg/kg IP	2 minutes	30 minutes
Pentobarbital	65mg/ml	30 mg/kg (7.5mg/250mg) 50mg/kg (10.5mg/250mg)	5 minutes 5 minutes	90 minutes 120 minutes
Telazol (tiletamine + zolazepam)	tiletamine 50mg/ml zolazepam 50mg/ml (1:1)	20mg/kg IP, IM 5mg/250g IP, IM	3-5 minutes	30-60 minutes
Inactin (EMTU - ethylmalonythiourea)	100mg/ml saline 10% solution	80mg/kg IP 20mg/250gm IP	3-5 minutes	3-4 hrs

*can be reversed with atipamezole (1mg/kg SQ ,IP or IV)