Use of Analgesics, Tranquilizers, and Anesthetic Agents in Laboratory Animals
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© 1997-2005
Updated 02 May 2005.
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Updated 15 July 2005
Department of Laboratory Animal Resources - Medical Care
Rat Analgesics
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Analgesic
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Brand Name
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Concentration
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Dose and Route
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Frequency
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Acetaminophen |
Tylenol |
Tablets or liquid
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110-300mg/kg
PO
25-75mg/250g) |
every 4 hrs
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Aspirin |
Various |
Tablets or liquid baby = 125mg/tablet adult = 325mg/tablet |
100mg/kg PO
2.5mg/250g) |
every 4 hrs
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Buprenorphine |
Buprenex |
0.3mg/ml
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0.1-1.5 mg/kg
SC, IP
0.025-0.1mg/250g |
every 6-12 hrs
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Butorphanol |
Torbugesic |
10mg/ml
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0.05-2 mg/kg
SC
0.012-0.5mg/250g |
every 4 hrs
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Nalbuphine |
Nubain |
10mg/ml
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1-2mg/kg IM
0.25-0.5mg/250g |
every 4 hrs
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Buprenorphine Jello Recipe
for rodent analgesia
Feed Jello without the drug to get the animals accustomed to the Jello. |
Synapse
Volume 25 #3, September 1992, pp36-37
1. Decide on the dose (0.1-0.5 mg/kg) is recommended.
(0.025-0.10mg/250g)
2 Determine dosage. Plan on one ml volume of Jello
per average weight of rat, thus, for example, 0.33 ml Buprenex per 0.66ml
of jello/250g rat.
3. Making enough Jello for twice daily dosing for up
to 4 days. Strawberry seems to be the favorite.
4. Follow the Jello recipe up to the part where you
dissolve the Jello in hot liquid. Reduce the volume of cold water by the
volume of Buprenex you will be adding first. Add the
cold H2O. Wait until mixture is less than 90F before adding Buprenorphine.
Pour into ice cube trays @ 4 ml/section. Freeze and administer 1 cube/4
rats twice daily.
5. Dose by giving 1/4 of a 4 ml cube per rat. place on cage floor on top of rodent food. |
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