Use of Analgesics, Tranquilizers, and Anesthetic Agents in Laboratory Animals
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© 1997-2005
Updated 02 May 2005.
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Updated 15 July 2005
Department of Laboratory Animal Resources - Medical Care
Mouse Anesthesia
|
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Anesthetic
|
Concentration
|
Dose and Route
|
Onset
|
Duration of Surgical Anesthesia
|
Mouse Cocktail
(Ketamine, Xylazine) |
Ketamine 30mg/ml
Xylazine 4mg/ml |
0.1-0.2ml/25
gm
IM, IP |
3-5 minutes |
30-40 minutes |
Isoflurane
(need precision vaporizer to deliver the agent) |
induction 4-5%
maintenance 1-2% |
Inhalation |
2-3 minutes |
until disconnected |
Halothane
(need precision vaporizer to deliver the agent) |
induction
4-5%
maintenance 1-2% |
Inhalation |
2-3 minutes |
until disconnected |
Medetomidine*
+ Ketamine |
Medetomidine
1mg/ml
Ketamine 100mg/ml |
M - 1 mg/kg
IM
K = 75mg/kg |
2 minutes |
30 minutes |
Mouse Cocktail
(Ketamine, Xylazine) |
Ketamine 30mg
and
Xylazine 4mg per ml of mouse cocktail |
0.1-0.2ml/25
gm IP |
3-5 minutes |
30-40 minutes |
Pentobarbital |
65mg/ml |
50mg/kg IP
(40-90 range) 1.25mg/25gm |
5 minutes |
30 minutes |
Rat Cocktail
(double strength mouse cocktail) |
Ketamine 60mg/ml
and
Xylazine 8mg per ml of rat cocktail |
0.05-0.1ml/25
gm
IP, IM |
3-5 minutes |
30-40 minutes |